Science · Body

Your Body Runs on More Than One Clock

Circadian, ultradian and infradian rhythms, and what sets them.

The question

Why do you feel sleepy at the same time each night, even without a clock?

The short answer

Nearly every cell carries a molecular clock that runs close to 24 hours, kept in time mainly by light. Shorter and longer rhythms run alongside it.

00:00 06:00 12:00 18:00 1 2 3 4 1 Melatonin rises About 2 hours before sleep 2 Lowest body temperature Early morning, before waking 3 Alertness climbs Mid-morning 4 Afternoon dip Early afternoon Shaded: sleep, 23:00 to 07:00
A typical day for someone who sleeps 11 pm to 7 am: melatonin rises in the evening, core temperature is lowest in the early morning.

What science knows

Established Science

In mammals a small brain region, the suprachiasmatic nucleus, acts as a master clock and is reset each day chiefly by light reaching the eyes. The 2017 Nobel Prize in Physiology or Medicine went to Jeffrey Hall, Michael Rosbash and Michael Young for uncovering the genes behind these clocks.

Kept away from daylight, most people’s rhythm drifts slightly longer than a day; one careful study measured an average near 24.2 hours.

The pattern

Established Science

Biological rhythms are grouped by their period:

RhythmPeriodExample
UltradianUnder 24 hoursSleep cycles of roughly 90 minutes
CircadianAbout 24 hoursSleep and wake, body temperature, melatonin
InfradianLonger than a dayThe menstrual cycle, commonly 21 to 35 days

What is still uncertain

Active Research

Whether a 90-minute rest-activity rhythm continues through the waking day, as Nathaniel Kleitman proposed, has mixed evidence. How much artificial light and screen time shift modern body clocks is an active field.

Why humans find it interesting

Historical Fact

In 1729 the astronomer Jean-Jacques d’Ortous de Mairan noticed that a mimosa plant kept opening and closing its leaves on schedule even in darkness: one of the first hints that living things keep their own time.

CUE perspective

CUE Perspective

CUE is about timing, and the body is proof that timing is real: the same task can feel easy at one hour and hard at another.

CUE’s daily readings use a separate, symbolic framework, not biology. But the idea that days have a rhythm worth working with is one science and CUE share.

Explore next

Sources

  • Nobel Assembly at Karolinska Institutet, The Nobel Prize in Physiology or Medicine 2017 (press release)
  • Czeisler et al., “Stability, precision, and near-24-hour period of the human circadian pacemaker”, Science 284 (1999)
  • Bull et al., “Real-world menstrual cycle characteristics of more than 600,000 menstrual cycles”, npj Digital Medicine 2 (2019)

Written by CUE from the sources above. Some topics were suggested by Polymath; its claims are not reproduced.